Anti-Alzheimer's Activity of aqueous extract of leaves of Murraya koenigii in Aluminium chloride Induced Neurotoxicity in rats
Reddy B. Maheswari1,*, Dhanapal C. K.2, Lakshmi B.V.S.1
1Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally, Maisamaguda, Secunderabad, 500100, Medchal, Telangana, India
2Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 8 August, 2019.
The present study was aimed to evaluate the protective effect of Murraya koenigii on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats.
Wistar albino rats were selected in this study and were divided into 6 groups (6each). Group I animals received saline and were considered as control. Group II rats were administered with AlCl3 (40mg/kg b.w, oral) for 35 days. Group III rats were treated with standard Vitamin E (100mg/kg b.w, p.o) and AlCl3 (40mg/kg b.w, oral). Group IV, V, VI received aqueous extract of leaves of Murraya koenigii (100mg/kg b.w, p.o, 200mg/kg b.w, p.o, 400mg/kg b.w, p.o) and inducing agent AlCl3 (40mg/kg b.w, oral). The rats were given respective treatment for 35 days and behavioural parameters were determined on the 35th day. On the 35th day the rats were sacrificed and antioxidant parameters, brain acetylcholinesterase content were determined.
Oral administration of aqueous extract of leaves of Murraya koenigii at doses 100, 200, 400mg/kg body weight showed improvements in behavioural parameters when compared to AlCl3 induced rats; showed increase in superoxide dismutase, catalase, reduced glutathione and decreased levels of malondialdehyde and also a showed decrease in brain acetylcholinesterase content when compared to AlCl3 induced rats.
This study strongly suggested that M koenigii could possibly restore the altered neurological capacities and antioxidant power in rats, and it could even be a good alternative to chemical medicines against AlCl3 induced neurotoxicity
Alzheimer's disease, AlCl3, Antioxidant parameters, Behavioural parameters, Murraya koenigii.