Synthesis, Characterization, Antimicrobial Evaluation of 2-Amino pyrimidine Schiff base derivative
Ramachandran S.*, Aanandhi M. Vijey, Tamilselvam M., Sursha V., Vigneshwara K. T.
Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, 600117, (India)
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 8 August, 2019.
Schiff base or imine is an analogue of a ketone or aldehyde in which the carbonyl group has been replaced by an imine or azomethine group. Schiff bases exhibits a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties Imine or azomethine groups are present in various natural, natural-derived and non-natural compounds. The imine group present in such compounds has been shown to be critical to their biological activities A new compound (Z)N_(4-dimethylamino) benzylidene) pyrimidine-2-aminewas synthesized by the reaction of 2-aminopyrimidine, 4-(dimethylamino) benzaldehyde and a drop of acetic acid in the presence of ethanol respectively. The chemical structures of the synthesized compounds were characterised by using Fourier Transform Infra Red Spectroscopy (FTIR), Proton Nuclear Magnetic Resonace Spectroscopy technique (1HNMR). The synthesized compound showed mild antibacterial activity against Staphylococcus aureus and Escherichia coli.
Antibacterial, Aromatic aldehyde, 2-amino pyrimdine, SchiffBase, Imine.