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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 4
First page : ( 1610) Last page : ( 1614)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00268.3

The effect of Calcium and Vitamin D Supplements as an Adjuvant Therapy to Metformin on Lipid profile in vitamin D Deficient/Insufficient Polycystic Ovary Syndrome Patients

Kaddoura Sally1,*, Alhalabi Marwan2,3, Nattouf Abdul Hakim1

1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, Damascus, Syria

2Department of Embryology and Reproductive Medicine, Faculty of Medicine, Damascus University, Damascus, Syria

3Assisted Reproduction Unit, Orient Hospital, Damascus, Syria

*Corresponding Author E-mail: sally.clinical@gmail.com

Online published on 8 August, 2019.


Objective: This study aims to investigate the impact of combining calcium and vitamin D supplements with metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome (PCOS) women. Study design: A randomized, placebo-controlled clinical trial. Setting: Damascus University of Obstetrics and Gynecology Hospital and Orient Hospital, in Damascus, Syria. Materials and methods: Forty PCOS women with 25-hydroxyvitamin D<30 ng/mL were randomly assigned to take either metformin (1500 mg/daily) plus placebo or metformin (1500 mg/daily) plus calcium (1000 mg/daily) and vitamin D3 (6000 IU/daily) orally for 8 weeks. Fasting serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG) and non-HDL cholesterol (non-HDL) were detected at the baseline and after 8 weeks of intervention. Results: Of all participants, thirty-four completed the study. After 8 weeks of intervention, calcium and vitamin D levels increased significantly in the supplementation group, but no significant changes in the lipid profile were noticed in both groups. Conclusions: Adding calcium and vitamin D to metformin therapy had no superior effect on improving lipid profile in vitamin D deficient/insufficient subjects with PCOS.



Polycystic Ovary Syndrome, Lipid Profile, Calcium, Vitamin D, Metformin.


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