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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 3
First page : ( 1244) Last page : ( 1250)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00207.5

A Comparative Evaluation Study of Citrus limetta and Metformin against Hyperlipidemia in Diabetic and Non-diabetic rats

Khan Ahmed Abdullah*, Siddiqui Hefazat Hussain, Ansari Tarique Mahmood, Ahsan Farogh

Faculty of Pharmacy, Integral University, Lucknow-226026, (U.P), India

*Corresponding Author E-mail: ansaritariq79@yahoo.co.in

Online published on 18 May, 2019.


Citrus limetta risso (Rutaceae) has been frequently used in Indian traditional medicine for the treatment of hyperlipidemia and promotion of weight loss. Studies also indicated towards the antihyperlipidemic potential of Metformin. This study was performed on high fat diet (HFD) induced hyperlipidemia in murine models in both presence and absence of diabetes which was induced by dose of 30mg/kg. Hyperlipidemia was induced by feeding rats with HFD for 28 days. Antihyperlipidemic effect of Citrus limetta peel extract (400mg/kg) and its main terpene component D-limonene (400mg/kg) was evaluated and compared with the effect of Metformin (200mg/kg) by the measurement of body weight gain, body mass index(BMI), food efficiency ratio, fasting blood glucose, Lee's index, heart to body weight ratio, serum lipid profiles (triglycerides, total cholesterol, HDL-Cholesterol, LDL-Cholesterol, VLDL-Cholesterol), end organ weights (Liver, heart, kidneys and visceral fat pad) and antioxidant enzymes such as Thiobarbituric acid (TBARS), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH). Histomorphological studies were also carried out. Citrus limetta extract, Dlimonene and Metformin significantly reduced the weight gain percentage, total cholesterol, LDL and VLDL and increased the level of HDL-cholesterol and antioxidant enzyme level in liver tissue, also controlled the other parameters’ value within their normal ranges. Histomorphological study of fat tissue shows the normalization of swollen and slight deteriorated cells in the treated groups as compared to control groups. This study concludes that Citrus limetta extract and D-limonene have the antihyperlipidemic activity.



Hyperlipidemia, Consumption, accumulation.


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