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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 3
First page : ( 1008) Last page : ( 1016)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00167.7

Preparation and Characterization of Novel disubstituted 1, 3-Oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2, 5-dione and 3-Phenyldihydrofuran-2, 5-dione

Ayfan Abdul Kareem Hamad1, Muslim Rasim Farraj2,*, Noori Noor Sabah3

1Pharmacy College, University Of Anbar, Anbar, Iraq

2Department of Ecology, College of Applied Sciences-Hit, University Of Anbar, Anbar, Iraq, dr.rasim92hmts@gmail.com

3Department of Chemistry, College of Science, University Of Anbar, Anbar, Iraq, noorahmed1988@yahoo.com

*Corresponding Author E-mail: kareemhamad7@gmail.com

Online published on 18 May, 2019.


This research includes synthesis of new heterocyclic derivatives of novel disubstituted 1, 3-oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2, 5-dione and 3-phenyldihydrofuran-2, 5-dione. Schiff bases [A1-A5] were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as catalyst in absolute ethanol. The novel derivatives[A6-A10] were obtained from treatment of Schiff bases with anhydrides. The synthesized compounds were identified by TLC and via spectral methods, their (FT-IR, 1H-NMR and 13C-NMR) and measurements of some of its physical properties.



1H-NMR, 13C-NMR, TLC, Schiff bases, oxazepine-tetra-one.


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