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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 2
First page : ( 693) Last page : ( 698)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00123.9

Effects of Dual-Task Training with different Intensity of Aerobic Exercise on Cognitive Function and Neurotrophic Factors in Chronic Stroke Patients

Kim Tae-Gon1, Bae Sea-Hyun2, Kim Kyung-Yoon2,*

1Department of Physical Therapy, Eunhye Hospital, 5–5, Geobukseongongwon 2-gil, Yeosu-si, Chonnam, 59676, Republic of Korea

2Department of Physical Therapy, College of Health and Welfare, Dongshin University 185, Gunjae-ro, Naju-si, Chonnam, Republic of Korea

*Corresponding Author E-mail: redbead7@daum.net

Online published on 18 April, 2019.



The present study aimed to investigate the effects of dual-task training with different intensity of aerobic exercise on cognitive function (MMSE-K, Trail making test, and Stroop test) and neurotrophic factors (BDNF, IGF-1) in chronic stroke patients.

Methods/Statistical analysis

The subjects were 27 stroke patients who met the study selection criteria, and were divided according to screening tests into the following: group I (low-intensity aerobic exercise plus dual-task training, n=9), group II (moderate-intensity aerobic exercise plus dual-task training, n=9), and group III (high-moderate-intensity aerobic exercise plus dual-task training, n=9). Subjects performed training 5 times a week, a total of 30 times in 6 weeks.


The results of the study showed that moderate-intensity aerobic exercise (p<.01) and high-intensity aerobic exercise (p<.001) showed significant differences between after training (p<.001). Significant differences between the groups were found after training, with a difference in MMSE-K between group I and III (p<.001) and between group II and III (p<.01). A significant difference was found between the groups in the Trail Making Test and the Stroop test (p<.001), with a difference after training between group I and III (p<.001) and between group II and III (p<.01). In addition, a significant difference was found between the groups in BDNF and IGF-1 levels (p<.001), with a difference between group I and III (p<.001) and between group II and III (p<.05).


Therefore, the present study found that the effectiveness of cognitive rehabilitation for stroke patients can be enhanced by using differentiated aerobic exercise rather than limited desktop activity



Dual task training, Aerobic exercise, Intensity, Cognitive function, Neurotrophic factor.


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