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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 2
First page : ( 574) Last page : ( 578)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00102.1

Hepato-Protective Studies of Poloxamer-188 by Paracetomol induced liver toxicity in Rats

Hussain T Arif1,*, MD Uddin Imad2, MD Uddin Irfan1, MD Nadeem1, Talha H1, Prashanth K1

1Dept. of Pharmacology, MAK College of Pharmacy, Moinabad, Hyderabad, Telanagana, 501504

2Dept. of Pharmacology, Pulla Reddy Institute of Pharmacy, Sangareddy, Hyderabad, Telanagana, 502313

*Corresponding Author E-mail: tarifpharma@gmail.com, imadpharma111@gmail.com

Online published on 18 April, 2019.


Poloxamer-188 (P-188) is a polymer well renowned for possessing medical properties. Present study was conducted with an aim to evaluate Hepato-protective potential of P-188 against paracetamol induced liver damage in wistar albino rats. Group-I served as Normal control which received normal saline 5ml/kg of Body weight (BW) for 7 days. Group-II served as Negative control in which animals received same dose as mentioned in Group-I. Group-III, IV and V animals received P-188(50mg/kg), P-188(100mg/kg) and silymarin (25mg/kg) respectively for 7 days. Except Group-I all other groups challenged with a very high dose of paracetamol (750 mg/kg) to induce hepatotoxicity. Biochemical estimation results showed that SGOT, SGPT and ALP levels were increased in negative control group animals which were decreased to normal levels when treated with P-188. There was highly significant (p<0.0001) decrease of these values in all three treatment groups. Moreover decrease in P-188 treated groups is dose dependent. Histopathological study supports the results of biochemical estimation. Negative control animal showed inflammation with mild cholestasis. P-188 (50mg/kg) showed mild inflammation, more number of normal hepatocytes, whereas P-188 (100 mg/kg) showed scattered lymphocytes among normal hepatocytes and kupffer cell hyperplasia, no incidence of inflammation and necrosis. Based on these results we can conclude that P-188 is a hepatoprotective polymer.



Poloxamer-188, Paracetamol, Hepato-Protective, Silymarin, Histopathological study.


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