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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 5841) Last page : ( 5844)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.01012.6

Diagnostic efficiency of Alpha Feto Protein, Hypothyroidism in Thalassemic patients with Liver Damage

Raoof Israa Burhan*, Daoud Aseel Ghassan

Department of Clinical Laboratory Science, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq

*Corresponding Author E-mail: israaburhan@uomustansiriyah.edu.iq

Online published on 24 February, 2020.


Thalassemia is a blood disease characterized by lack or absence in the synthesis of globulin chains either α, β causing major, minor and intermediate. Diagnostic patients with multiple transfusions used AFP as akey predictor for early diagnosis of disease. It was found on laboratory tests, the types of mutation among most severely affected in Iraqi patients is major thalassemia. Lab investigations appeared significant decrease of Mean Corpuscular Volume (MCV) but no significant in Mean corpuscular hemoglobin (MCH), adult Hemoglobin A (HbA) while significant increase of Ferritin, Fetal Hemoglobin (HbF), adult Hemoglobin A2 (HbA2) in patients as compared with control groups, Prevalence of hypothyroidism with disorder in liver functions was noticed with significant increase of Alpha Feto Protein (AFP) as compared with healthy subjects. Finally, there was significant correlation of Ferritin with Hb, Alk. P, AST while significant correlation of AFP with Ca, ALT but no significant correlation between AFP and TSB was demonstrated.



Thalassemia, Hypothyroidism, Ferritin, AFP.


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