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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 12
First page : ( 5683) Last page : ( 5688)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00983.1

Antioxidant Potency of Okra (Abelmoschus esculentus Moench) Pods Extract on SOD Level and Tissue Glucose Tolerance in Diabetic Mice

Husen Saikhu A.1,2, Wahyuningsih Sri P. A.1, Ansori Arif N. M.3, Hayaza Suhailah1, Susilo Raden J. K.1, Winarni Dwi1,2, Punnapayak Hunsa4, Darmanto Win1,*

1Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, Surabaya, Indonesia

2Animal Histology Laboratory Faculty of Science and Technology, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, Surabaya, Indonesia

3Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, Surabaya, Indonesia

4Department of Botany, Faculty of Science, Chulalongkorn University, 10330, Bangkok, Thailand

*Corresponding Author E-mail: windarmanto@fst.unair.ac.id

Online published on 24 February, 2020.

Abstract

The purpose of this study was to determine the effect of various fractions of okra pods extract (VOPE) on superoxide dismutase (SOD) level and tissue glucose tolerance in the streptozotocin (STZ) induced diabetic mice. This study was using 35 male Balb/c strain mice. The samples were divided into seven groups, namely KN (normal control), KD (diabetic control), KA (acarbose control), EK (crude extract), NP (non-polar), SP (semipolar), and EP (polar). VOPE and acarbose suspension were administered orally for 14 days in the STZ-induced diabetic mice. Intraperitoneal injection of multiple low-dose STZ (30mg/kg body weight) induced diabetes daily for five consecutive days. On the 15th day, the mice were terminated. Data of SOD level and tissue glucose tolerance were analyzed by ANOVA, at α = 0.05. This study concluded that the administration of VOPE could increase SOD level and tissue glucose tolerance in the STZ-induced diabetic mice. In conclusion, VOPE is a promising antioxidant agent due to its antihyperglycemic properties.

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Keywords

Abelmoschus esculentus Moench, Diabetic Mice, SOD Level, Tissue Glucose Tolerance.

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