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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5633) Last page : ( 5640)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00975.2

Overview on Trends in Development of Gastroretentive Drug Delivery System

Suradkar Pavan, Mishra Rakesh*, Nandgude Tanaji

Department of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Science & Research, Pimpri, Pune-411018, Maharashtra, India

*Corresponding Author E-mail: mishrarakesh287@gmail.com

Online published on 9 April, 2020.

Abstract

The present review on gastroretentive Drug Delivery Systems was aim with overview on various trends in development of gastroretentive approaches in the area of site-specific orally administered controlled release drug delivery. Gastroretentive dosage form can improve the delivery and performance of drug into the stomach because the drug remains in stomach for sufficient time of interval. The review summarized various physiological requirements and factors affecting gastric retention with merit and demerits of gastroretentive system. Various gastroretentive approaches designed and developed by researchers such as high density (sinking), floating system, bioadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems were highlighted in the article.

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Keywords

Gastroretentive Drug Delivery System, Floating System, Effervescent System and Bioadhesive System.

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