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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5561) Last page : ( 5565)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00964.8

Analytical Methods for the determination of drugs used in Alzheimer's disease-A Review

Sheela Avuthu Sai, Annapurna Mukthinuthalapati Mathrusri*

Department of Pharmaceutical Analysis & Quality Assurance, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, AP-530045, India

*Corresponding Author E-mail: mannapurna.mukthinuthalapati@gitam.edu

Online published on 9 April, 2020.

Abstract

Alzheimer's disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks. Alzheimer's disease is the most common cause of dementia among elder adults. Till now there are no medications which cures Alzheimer's disease or alters the disease process in the brain. The exact causes of Alzheimer's disease are not understood. But scientists believe in most of the people, it is caused by a combination of genetic, lifestyle and environmental factors that affect the brain over time. Problems with brain proteins leads to failure of normal functioning of brain which may disrupt the working of brain cells (neurons) which produces toxic events. Some of the drugs used are Donepezil, Rivastigmine, Galantamine, Memantine. A brief review of the analytical Methods developed for the estimation of the above drugs was discussed in the present study.

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Keywords

Analytical Methods, drugs, Alzheimer's disease.

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