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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5260) Last page : ( 5264)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00910.7

A Comparative Study on effect of the Sedative Drugs (Tramadol and Fentanyl) on the Intraoperative Agitation in patients with Cesarean section (C/S) using ASA assessment in Baghdad Educational Hospital

Ali Zina Tariq*

Lecturer, College of Health and Medical Technology, Middle Technical University, Baghdad, Iraq

*Corresponding Author E-mail: drnihadkhalawre@gmail.com

Online published on 9 April, 2020.


Many of serious events such as severe injuries from falling out of the bed, self-extubation, hemorrhage as well as even removal of catheters that arise due to agitation. A postanesthetic phenomenon that advances in the initial phase of general anesthesia recovery can able to describe as agitation which characterized by potential violent behavior, disorientation and confusion. Additionally, it may cause medical staff injuries. This study was intended to assess and compare the sedative effect of the tramadol and fentanyl in prevention of agitation postoperatively for patients under went for cesarean section (C/S). The current study commenced in the obstetric and cesarean section department/Baghdad Teaching Hospital/Medical City/Baghdad-Iraq. The study involved fifty (50) pregnant females-their age ranged (20–45) years underwent cesarean section (C/S) under general anesthesia. The patients were distributed equally into (2) two groups; group (A): were received Fentanyl (50mcg), while second group(B) were received Tramadol (100mg). Patients were pre-medicated with metoclopramide (10mg), ranitidine (50mg) as well as dexamethasone (8mg) intravenously. The maintenance of anasethseia was inducing by oxygen 100% sevoflurane 2%, the umbilical cord of neonate was clamped. The sedative drugs (tramadol and fantanyl) were administrated to group (A) and group (B) respectively. Based on Sedation-Agitation scale, of fifty (50) pregnant females. Fentanyl and tramadol produced significant calm and cooperative (grade 4) in thirty-nine (39) females, but both drugs did not produce significant sedative effect (grade 3) in the females. In tramadol group, three (3) females were anxious and agitated and three (3) females were developed agitation. Fentanyl and tramadol were effective in prevention of agitation, but fentanyl, as compared with tramadol may have a greater beneficial effect for reducing the agitation postoperatively.



Tramadol, fentanyl, agitation, cesarean section (C/S).


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