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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 11
First page : ( 5231) Last page : ( 5239)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00905.3

Development, Optimization Characterization and In vitro study of Rosmarinic acid phytovesicles

Sethi Bhawana1, Sahdev Anil Kumar2,*, Purwar Somya2

1Faculty of SGT College of Pharmacy, Department of Pharmaceutics, Sgt University, Budhera, Gurugram, Haryana, 122505. India

2Faculty of GNIT College of Pharmacy, Greater Noida, Uttar Pradesh, 201306, India

*Corresponding Author E-mail: anilsahdev20@gmail.com

Online published on 9 April, 2020.


There are many herbal extracts and Phyto-constituents having excellent bioactivity in vitro but less in vivo because of their poor solubility and improper size of the molecule or both, which result in poor absorption and bioavailability of herbal extract or constituents from herbal extract and they destroyed in the gastric fluids when taken orally. Phyto-vesicles is the novel emerging technique applied to phyto-pharmaceutical for the enhancement of bioavailability of herbal extract or plant phytoconstituents for medicinal applications. Rosmarinic acid (RA) has a number of interesting biological activities, e.g. anti-viral, antibacterial, anti-inflammatory and antioxidant. Despite its strong antioxidant activity and anti-inflammatory activity, it was limited to use in medicine because of the low water solubility, discolouration and chemical instability. Objective of the present study was to develop vesicular system for delivery of Rosmarinic acid to achieve enhanced topical bioavailability. Complex of Rosmarinic acid with phosphatidyl choline (PC) was prepared and characterized. Optimization is also performed to find out the best possible combination. The complex was further converted into vesicles (phyto-vesicles). This study is indicated that the optimize batch have highest entrapment efficacy and better drug release profile.



Polyphenols Enhanced Bioavailability, Phospholipid, Herbal Extract, Phytoconstituents, Phospholipid-Phytoconstituent complex, Rosmarinic acid.


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