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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4958) Last page : ( 4962)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00860.6

Fennel Treatment to PCOS: An Insilico Evaluation to explore the Therapeutic Efficacy of Anethole

Chandran Arunima, Merlin N J*, Ammu L, Dharan Shaiju S

Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Neyyantikara – 695124, TVM

*Corresponding Author E-mail: merlinbinu76@yahoo.co.in

Online published on 24 December, 2019.


Polycystic ovary syndrome (PCOS) or polycystic ovary disease (PCOD) is an extremely most common endocrine and metabolic disorder recognized as the primary cause of infertility. PCOS produces symptoms in approximately 5–10% of women of their reproductive age. Features of PCOD may manifest at any age, ranging from childhood (premature puberty), teenage years (hirsutism, menstrual abnormalities), early adulthood, and middle life (infertility, glucose intolerance) to later life (diabetes mellitus and cardiovascular diseases). Anethole is an important constituent of fennel which is having diuretic, analgesic, antipyretic and antioxidant activities. Phytoestrogene is an active biological substance which can act similar to estrogen. The drug target interaction was investigated using in-silico docking studies. The insilico study provides evidence for the interaction of anethole with the target proteins namely androgen receptor, insulin receptor substrate 1(IRS 1) and follicle stimulating hormone (FSH) receptor. This interaction is presumably vital in exerting the PCOS activity. The present study clearly elucidates that anethole possesses PCOS activity.



PCOS, Fennel, Anethole, Infertility, Docking.


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