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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4909) Last page : ( 4912)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00850.3

Biochemical Markers of Bone Turnover in Pre-dialysis, Chronic Renal Failure Patients

Jasim Aziz H.1,*, Al-Saadi Narjis Hadi2

1Department of Pathological Analysis, College of Medical Technology, Ibn Hayyan University, Iraq

2Department of Chemistry, College of Science, University of Kerbala, Iraq

*Corresponding Author E-mail: azizhusain750@yahoo.com

Online published on 24 December, 2019.



Bone disorders and bone resorptions were observed initiate early in the route of kidney failure. This reason led to investigates of examined the severity and frequency of the skeletal disorders in pre-dialysis chronic renal failure (CRF) patients by estimates a biochemical markers of bone turnover, vitamin D metabolites, thyroid hormones [triiodothyronine (T3), tetra iodothyronine (T4)], and serum calcium (Ca+2) concentrations.


The study was included 70 patients (male/female: 40/30) with chronic kidney disease [mean glomerular fltration rate (GFR) is < 15 ml/min] and 50 healthy subjects as a control group.


The results showed highly significant increase (P > 0.001) to levels of bone markers (Vit. D, Ca+2), and revealed highly significant decrease to thyroid hormones (T3, T4) with the more advanced stages of kidney failure when compared with control group. Moreover, the results showed strong positive correlations between Vit.D with Ca+2; and T3 with T4 (r = 0.859, r = 0.767) respectively. Also the results showed a strong negative correlations between Vit.D with T3; Vit.D with T4; T3 with Ca+2; and T4 with Ca+2 (−0.813, -0.691, -0.878, -0.774) respectively.


A high levels of bone resorption result in reduced bone density, and its present in early stage of Chronic renal failure (CRF) [GFR 6 to 70 ml/min], by assessment of elevated serum thyroid hormones (T3, T4), and elevated of biochemical markers (vitamin D and Ca+2) levels.



Bone disorders, renal osteodystrophy, Pre-dialysis.


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