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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4867) Last page : ( 4872)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00843.6

Stability indicating RP-UPLC method for the simultaneous determination of Atorvastatin and Amlodipine

Chaithanya Sunkara Mrunal*, Annapurna Mukthinuthalapati Mathrusri

Department of Pharmaceutical Analysis & Quality Assurance, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh-530045, India

*Corresponding Author E-mail: mrunal.chaitanya@gmail.com

Online published on 24 December, 2019.

Abstract

Amlodipine is a calcium channel blocker. Atorvastatin is used for lowering the cholesterol. A new stability indicating liquid chromatographic method (RP-UPLC) has been proposed for the simultaneous estimation of Atorvastatin and Atorvastatin. Acquity UPLC HSS C18 column was used for the chromatographic study and a mobile phase mixture consisting of 0.1% Formic acid: Acetonitrile: Methanol (0.1:45: 55, v/v)/0.3/220 (Flow rate: 0.3 mL/min) (PDA detector 220 nm) was used for the elution of these two drugs. Stress degradation studies were performed and the method was validated as per ICH guidelines.

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Keywords

Atorvastatin, Atorvastatin, RP-HPLC, stability indicating, validation.

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