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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4857) Last page : ( 4860)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00841.2

Development of UV Spectrophotometry Absorption correction method for estimation of Curcumin and Aspirin from Bulk

Sahu Sukanya, Kumari Khusbu, Muduli Nihar Ranjan, Moharana Alok Kumar*

Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar-751003, Odisha, India

*Corresponding Author E-mail: moharana20@gmail.com

Online published on 24 December, 2019.

Abstract

The present study describes method development and validation of aspirin and curcumin simultaneously by absorption correction method by UV spectroscopy. The maximum wavelength selected for this method were 227nm and 427nm for aspirin and curcumin respectively with ethanol. The described method was linear at 2–12 μg/ml for aspirin 1–6 μg/ml for curcumin. The correlation coefficient was 0.999 for both aspirin and curcumin. The recovery of the drugs was above 95%. The interday and intraday precision were within the limit for both the drug (RSD <2). The proposed method is simple, accurate and cost effective which can be used for analysis of both drugs from bulk and new formulations.

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Keywords

Aspirin, Curcumin, Validation, UV, Formulation.

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