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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4827) Last page : ( 4830)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00835.7

Derivative spectrophotometric methods for the assay of Glibenclamide (An anti-diabetic agent)

Annapurna Mukthinuthalapati Mathrusri*, Bhanu Palyam, Navya Kandula Venkat

Department of Pharmaceutical Analysis & Quality Assurance, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh-530045, India

*Corresponding Author E-mail: mannapurna.mukthinuthalapati@gitam.edu

Online published on 24 December, 2019.

Abstract

Glibenclamide is an anti-diabetic agent used for the treatment of diabetes mellitus type 2. First derivative spectrophotometric techniques were developed for the assay of Glibenclamide tablet dosage forms in three different reagents and the methods were validated. Glibenclamide has shown linearity over the concentration range 1–80, 1–100 and 1–80 μg/ml respectively in phosphate buffer pH 2.0 (Method A), phosphate buffer pH 8.0 (Method B) and borate buffer pH 9.0 (Method C) respectively. The methods were validated by precision and accuracy studies and are suitable for the determining the assay of Glibenclamide tablets.

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Keywords

First order derivative spectroscopy, Glibenclamide, Phosphate buffers, Borate buffer, Validation, ICH guidelines.

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