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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4790) Last page : ( 4794)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00827.8

New first derivative spectrophotometric methods for the estimation of Bumetanide in tablet dosage forms

Annapurna Mukthinuthalapati Mathrusri*, Sheela Avuthu Sai, Yasaswini Rangisetty Spandana

Department of Pharmaceutical Analysis & Quality Assurance, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh-530045, India

*Corresponding Author E-mail: mannapurna.mukthinuthalapati@gitam.edu

Online published on 24 December, 2019.


First derivative spectrophotometric methods have been developed for the assay of Bumetanide using Shimadzu UV-1800 Model double beam UV-VIS spectrophotometer in reagents such as hydrochloric acid, phosphate buffer pH 3.6, phosphate buffer pH 2.0 and distilled water. Bumetanide has shown linearity 10–70 μg/ml in all the methods and the linear regression equations are found to be y = 0.0015x -0.0013 (R² = 0.9993), y= 0.0007x 0.0004 (R² = 0.9991), y = 0.0014x -0.0015 (R² = 0.9993) and y = 0.0014x -0.0015 (R² = 0.9995) in hydrochloric acid, phosphate buffer pH 3.6, phosphate buffer pH 2.0, and distilled water respectively. The methods are validated as per ICH guidelines and found to be precise, simple and accurate.



First order derivative spectroscopy (D1), Bumetanide, Hydrochloric acid, Phosphate buffer, Validation, ICH guidelines.


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