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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4696) Last page : ( 4698)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00808.4

Development of the Technique of Quantitative Determination of Antracene derivatives in roots of Rheum officinale

Nikolaevna Semeniuta Ksenia1,*, Alexandrovich Kurkin Vladimir2, Anatolyevna Shmygareva Anna1, Nikolayevich Sankov Anatoly1

1Department of Economics of Pharmacy, Pharmaceutical Technology and Pharmacognosy, Orenburg State Medical University, Orenburg Oblast, Russia

2Department of Pharmacognosy, Botany and Phytotherapy, Samara State Medical University, Samara Oblast, Russia

*Corresponding Author E-mail: evdkn@mail.ru

Online published on 24 December, 2019.

Abstract

This paper discusses the current aspects of improvement of methods of standardization of roots of Rheum officinale. The new approaches are proposed for the quantitative analysis of the content of anthracene derivatives of roots of Rheum officinale, which consists in the using of the method of spectrophotometry at analytical wavelength of 510 nm calculated on Frangula-emodin and the use of ultrasound for the maximum yield of anthracene derivatives of raw materials and reducing the time of extraction in a water bath. The existing method for the determination of anthracene derivatives in the roots of Rheum palmatum presented in the State Pharmacopoeia of the Russian Federation, XIV edition, provides for a long extraction in a water bath. The use of physical factors, such as ultrasound, increases the yield of biologically active substances in the extraction due to the destruction of the cell structure, which reduces the extraction time.

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Keywords

Rheum officinale B, Rheum palmatum L, roots, anthracene derivatives, Frangula-emodin, standardization, spectrophotometry.

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