Adsorption of Atenolol drug from Aqueous solution by poly (AAM_MA) hydrogel and used in Drug Delivery System: Study kinetic and Thermodynamic
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In this study using poly acryl amid-co-maleic acid as effective adsorbent for Atenolol to adsorption from aqueous solution, Batch experiments done to study influencing some parameters such as contact time, weight of adsorbent, temperature, pH and ionic intensity to adsorption atenolol drug on hydrogel prepared previously by free radical polymerization from acrylamide (AAM) maleic acid(MA), by adsorption process of Atenolol we obtained data about kinetic and thermodynamic, describe kinetic by two models equation first and second pseudo order, also applied data on Langmuir, freundlich and Timken models equation to get it information on adsorption process, the study clarify effect some parameter on quantity of adsorbate such as pH at range (1.2–11). ionic strength by used three types of salts, temperature at rang (5–35)°C, contact time(1–300 min) and weight of adsorbate at range(0.01–0.20 g), its found when increase of temperature and ionic strength will decrease of quantity the adsorbate presences by using poly (AAM-MA) hydrogel under the following optimum condition at temperature 15oc, contact time 120 min, pH =6 found can removed 94.2% from drug in aqueous solution and adsorption process follow second pseudo order)R2 = 0.999).The adsorption isotherm appears that adsorption process applied models freundlich and Timken. Thermodynamic functions process calculated and appeared the adsorption non spontaneous and exothermic process, The aim of study kinetic and thermodynamic of adsorption Atenolol drug from aqueous solution to achieve highest level from therapeutic effectiveness to atenolol drug by cross linked hydrogel in controlled release system
Hydrogel, Adsorption process, Beta blocker drugs group, Controlled release, Drug carriers, Hypertension, Giles classification, Bioavailability.