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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 10
First page : ( 4669) Last page : ( 4677)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00804.7

Medication Error in Hospitals and Effective Intervention Strategies: A Systematic Review

Shitu Zayyanu1, Aung Myat Moe Thwe2, Kamauzaman Tuan Hairulnizam Tuan3, Bhagat Vidya2, Rahman Ab Fatah Ab1,*

1Faculty of Health Sciences, Faculty of Pharmacy, Universiti Sultan Zainal Abidin, 21300, Gong Badak Campus, Kuala Terengganu, Malaysia

2Faculty of Medicine, Universiti Sultan Zainal Abidin, 20400, Kota Campus, Kuala Terengganu, Malaysia

3Emergency Medicine Department, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia

*Corresponding Author E-mail: 55vidya42@gmail.com

Online published on 24 December, 2019.



Medication error (ME) posing a challenge to health care systems across the world; which is posing a challenge to health care systems across the world which has increased the risk of death of patient also the consumption cost approximately $42 billion annually in healthcare expenditure. Different types of interventions; including manual physician order reviews and electronic prescription order entry have been proposed as potential solutions to help combat this issue.


To analyze clinical studies on medication errors to assess implemented intervention strategies and measured outcomes, to determine the effective intervention practices with reduced medication errors.


Analysis of meditational error achieved through a systematic review. A search of PubMed was conducted to identify research studies on ME published between May 1960 and June 2017 in English.


The types of interventions discussed by computerized physician order entry (CPOE), Pharmacist and computerization, Automatic dispensing cabinets, and bar-coded assisted medication. The number of effective interventions used was [85%, 17/20] decreased the proportion of medication error while [15%, 3/20] interventions, recorded an increase in the proportion of medication error. The CPOE was found to intercept the highest of error [96%] followed by computer-assisted prescription [86%] and Clinical Pharmacist intervention [80%]. Conclusion: Most of the interventions used were found effective in reducing the occurrence of medication errors. The most common intervention used was CPOE by Clinical Pharmacist and Computerization; which was the most effective intervention strategy, followed by Clinical pharmacist, computerization, Automatic dispensing cabinets, and bar-code.



Medication errors MEs, Interventions, CPOE.


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