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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 1
First page : ( 241) Last page : ( 244)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00045.3

Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn

D'Souza Sonal, Fernandes Jennifer*, Kumar M Vijay, D'Souza Nishmitha Gretta, Fernandes Ronald

Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University)Paneer, Deralakatte, Mangalore-575018

*Corresponding Author E-mail: fernandesj@nitte.edu.in

Online published on 16 March, 2019.


The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.



Annona reticulata, antiepileptic activity, MES, PTZ.


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