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Research Journal of Pharmacy and Technology
Year : 2019, Volume : 12, Issue : 1
First page : ( 231) Last page : ( 236)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2019.00043.X

Chromatographic Analysis of Famotidine, Paracetamol and Ibuprofen from Tablet Formulation

Panchale Wrushali A.*, Suroshe Rajnandini, Rathod Minakshi S., Pandhare Yuvraj L.

MUP's College of Pharmacy (B. Pharm), Degaon, 444506, Dist. Washim, Maharashtra, India

*Corresponding Author E-mail: wpanchale@gmail.com

Online published on 16 March, 2019.

Abstract

Aim of the present work was to develop Reversed phase HPLC method for simultaneous estimation of famotidine (FAM), paracetamol (PCT) and ibuprofen (IBU)in bulk drug and tablet formulation. Separation was carried out on Nucleosil C-18 (15cm, 4.6 mm I.D × 250 mm) using a mobile phase methanol and water (ophosphoric acid, 0.05%) (83: 17, v/v) at a flow rate of 0.7 ml/min. The detection wavelength was set at 270 nm. Retention time of FAM, PCT and IBU were found to be 1.81, 2.58 and 8.58 min respectively. Linear relationship was found in the concentration range of 0.5–3 μg/ml for FAM (r2 = 0.999), 5–25 μg/ml for PCT (r2 = 0.999) and 5–30 μg/ml for IBU (r2 = 0.999). The % purity was found to be 98.40±1.49, 99.86±0.27 and 100.31±0.76, for FAM, PCT and IBU, respectively. The proposed method was validated as per ICH Q2 (R1) guidelines. The mean % recoveries were found be 100.90±1.99, 99.96±0.97 and 100.51±1.72 for FAM, PCT and IBU, respectively.

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Keywords

Famotidine, Paracetamol, Ibuprofen, RP-HPLC, Validation.

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