Protective effect of Cod Liver Oil in Experimentally Induced Gastric Ulceration in Rats Narkhede Kiran P.1, Satapathy Trilochan2,*, Pandit Bibhas2 1Department of Pharmacology, PRIST University, Thanjavur-614904, Tamilnadu, India 2Columbia Institute of Pharmacy, Near Vidhan Sabha, Tekari, Raipur, Chhattisgarh, Pin-493111, India *Corresponding Author E-mail: drtsatapathy@gmail.com
Online published on 16 March, 2019. Abstract Background Gastric ulcer is a life style disease, observed when gastric mucosa is exposed to the acid-pepsin mixture (APM) for prolonged period of time. The reason to undertake the present study is based on the scientific evidence that the cod liver oil found to possess a significant antioxidant and protective action against inflammation. However, there was no scientific proof established regarding the antiulcer activity of cod liver oil. As inflammation is one the causes of gastric ulcer, the present work was designed to evaluate the anti-ulcer efficiency of cod liver oil in three different ulcerated rat models. Methods Ulcer was induced through pyloric ligation, ethanol, and aspirin. The effect of Cod liver oil was evaluated by estimating the pH of the gastric juice, volume of gastric juice, ulcer scores, free acidity, total acidity as well as mucin content in the ulcerated rat models. The degree of ulcer protective consequence was explored by comparing the data with standard drugs i.e. omeprazole and sucralfate. Results Cod liver oil exhibited a significant mucosal protection and anti-secretory action in all three models. Cod liver oil showed percentage ulcer protection of >50% in pyloric ligation, ethanolinduced and aspirin-induced ulcer model when compared to standard drug omeprazole and sucralfate. Conclusion The findings from the present study indicated that the use of cod liver oil in gastric ulcer may be beneficial as it showed significant mucoprotective and anti-secretory activity in ulcerated rat models. Graphical Abstract 
Top Keywords Anti-ulcer, cod liver oil, pylorus ligation, ethanol-induced ulcer, aspirin. Top |