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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 3990) Last page : ( 3992)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00733.3

Detection of Inducible Clindamycin Resistance among Clinical Isolates of Staphylococcus aureus

Bharadwaj1, Dr. Gopinath P2

1BDS, Saveetha Dental College, Saveetha University, Chennai

2Senior Lecturer, Department of Microbiology, Saveetha Dental College, Saveetha University, Chennai

Corresponding Author E-mail:

Online published on 20 December, 2018.

Abstract

The resistance to antibiotic employed against staphylococcal isolates is an alarming problem. This has led to show intrest in using Macrolid-Lincosamide Streptogramin B (MLSB) antibiotics to treat infection produce by S. aureus. In vitro test for detecting clindamycin suspectibility may fail to detect inducible clindamycin resistance due to presence of erm gene which Results in treatment failure. A total of 20 clinical isolates of S.aereus were subjected to antibiotics suspectibility testing by disc diffusion method. Inducible resistance to clindamycin was detected by D-test as per CLSI guideline.20% isolates of were positive for iMLB phenotype, while 15% isolates were belong to MS phenotypes. This study showed that D-test can be used as a routine method in detecting inducible clindamycin resistance along with disc diffusion in S.aureus.

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Keywords

Clindamycin resistance, constitutive MLSB phenotype, inducible MLSB phenotype, MRSA, MS phenotype.

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