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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 3969) Last page : ( 3972)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00729.1

Synthesis and In-Vitro Anti-Inflammatory Activity of New Pyrazoline Derivatives

Bhat K. Ishwar*, Revanasiddappa B. C., Kumar M. Vijay, Felicity Banylla, Kumari Ranee, Kumar Abhishek

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of NITTE (Deemed to be University), xiad , Mangalore-575 018, Karnataka, India

*Corresponding Author E-mail: bhatishwar@yahoo.co.in

Online published on 20 December, 2018.

Abstract

A new series of Chalcones (2a-i) were prepared by Claisen-Schmidth Condensation reaction involving substituted aromatic aldehydes and aromatic ketones in alcohol medium, in presence of 40% NaOH as base. The title compounds Pyrazolines (3a-i) were synthesized by reacting Chalcones (2a-i) and 2-thiophene carbohydrazide (1) in glacial acetic acid medium. The final synthesized compounds were screened for their Invitro anti-inflammatory activity by egg albumin denaturation method and protein denaturation method. The structures of the newly synthesized compounds were assigned on the basis of IR, 1H-NMR and Mass spectral data. The compounds 3b, 3c, 3d and 3f also showed good inhibition when compared to the standard diclofenac sodium

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Keywords

Chalcones, Pyrazolines, Anti-inflammatory activity, Protein denaturation method.

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