Synthesis and In-Vitro Anti-Inflammatory Activity of New Pyrazoline Derivatives Bhat K. Ishwar*, Revanasiddappa B. C., Kumar M. Vijay, Felicity Banylla, Kumari Ranee, Kumar Abhishek Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of NITTE (Deemed to be University), xiad
, Mangalore-575 018, Karnataka, India *Corresponding Author E-mail: bhatishwar@yahoo.co.in
Online published on 20 December, 2018. Abstract A new series of Chalcones (2a-i) were prepared by Claisen-Schmidth Condensation reaction involving substituted aromatic aldehydes and aromatic ketones in alcohol medium, in presence of 40% NaOH as base. The title compounds Pyrazolines (3a-i) were synthesized by reacting Chalcones (2a-i) and 2-thiophene carbohydrazide (1) in glacial acetic acid medium. The final synthesized compounds were screened for their Invitro anti-inflammatory activity by egg albumin denaturation method and protein denaturation method. The structures of the newly synthesized compounds were assigned on the basis of IR, 1H-NMR and Mass spectral data. The compounds 3b, 3c, 3d and 3f also showed good inhibition when compared to the standard diclofenac sodium Top Keywords Chalcones, Pyrazolines, Anti-inflammatory activity, Protein denaturation method. Top |