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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3589) Last page : ( 3598)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00661.3

Cytotoxic and Antimicrobial Activities of Piperazine Bridged dithiocarbamate Homo Binuclear Mixed Ligand Complexes of Cu(II) with Amino acids

Malathy D.*

Assistant Professor, Department of Chemistry, School of Basic Science, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai-600117

*Corresponding Author E-mail: dm.malathy@gmail.com

Online published on 31 October, 2018.

Abstract

A new series of Cu(II) mixed ligand complexes with bridging piperazine dithiocarbamate along with chelated amino acids such as glycine, alanine, phenylalanine, methionine, tyrosine and cystine in the deprotonated form have been prepared. The synthesized complexes are characterized by thermal, elemental, metal, nitrogen and sulphur, UV-Vis, infra-red, ESR Spectral analysis magnetic susceptibility and powder XRD studies. The above studies are used for establishing the structure and composition of the complexes. Biological evaluation such as antibacterial, antifungal and anticancer properties have also been carried out on these complexes based on agar disc diffusion and MTT based assay method respectively

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Keywords

Piperazine dithiocarbamate, Cu(II), amino acids, antibacterial, antifungal and anticancer.

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