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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3561) Last page : ( 3571)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00656.X

Tight Junctions and their Role in Cancer: A Review

Rambabu Majji, Kanggeyavelu Jeipreethi, Jayanthi Sivaraman*

Computational Drug Design Lab, School of Bio Sciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India

*Corresponding Author E-mail: jayanthi.s@vit.ac.in

Online published on 31 October, 2018.

Abstract

The dynamic structure of Tight junction (TJ) is due to the change in conformation of the pores in the cells which accounts to the absolute polarity and differentiation so as to cause effective metastatic movement of cells through the blood vessels to target far-off site. Tight junctions are known for its prevalence in both endothelial and simple epithelial cells but occludin functional detection is absent in epithelial cell layer. The study on endothelial cell function in claudin, a tetraspanic membrane protein (20–27 kDa) is critic since it controls not only the morphology, fence and barrier function in membrane but also the pathological effects on the cellular environment. Amino acid residues in the TJ have proved to be a valuable and direct target for kinases and proteins. Our interest is also to understand the role and association of other tight junction protein family with claudin as well as signalling pathways that are involved in association with claudin in metastatic function. Thus, our insight view in this review paper is to understand the novelty of claudin that can be utilized as an efficient biomarker and predictor of cancer, cell specificity determined due to upregulation or downregulation of claudins, mutations in the cells and the expression of claudin in different cancer cell lines. This gives us an idea that claudins can be used as a drug target for cancer.

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Keywords

Cancer, Claudin, Kinases, Tight junction, drug target.

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