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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3543) Last page : ( 3546)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00654.6

A Systematic Review of Intrinsic Factors and its Influence in Breast Cancer

Hariramani Nidhi, Jayanthi Sivaraman*

Computational Drug Design Lab, Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India

*Corresponding Author E-mail: jayanthi.s@vit.ac.in

Online published on 31 October, 2018.

Abstract

Carcinogenesis is a process in which normal cell of the body is altered into cancer cell. It is characterized by genetic variation that effects key cellular pathways involved in progression and development. In cancer, cells tend to proliferate in an enormously and untimely way due to change in its metabolism and behavior. Breast cancer is most frequent and prime cause of women cancer mortality worldwide. Breast cancer is an outcome from mutations in a gene which are either present in the germ line of the infected individual or which are acquired in the breast cells. The proportion of breast cancers triggered by germline mutations. Although onefifth women affected of breast cancer found to have one relative with breast cancer. However, inheritance of germline mutations is estimated in breast cases is less (5%-10%). Thus, it is apparent that an understanding genetics of the breast cancer has turn into more relevant in the monitoring of pathogenesis. This review has been focused on presence of various intrinsic factors in breast cancer and how it is significance in the present scenario of advance therapeutics treatment.

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Keywords

Estrogen Receptor, Endocrine Resistance, LMTK3, FOXO, Therapy.

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