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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3534) Last page : ( 3542)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00653.4

Five-year Survival of Osteosarcoma Patients in Hospital Universiti Sains Malaysia (HUSM): An Eleven Year Review

Wahidah Tumijan1, Khattak Muhammad Naeem2, Wan-Arfah Nadiah3,*, Naing Nyi Nyi3

1Faculty of Sport Science and Recreation, Universiti Teknologi Mara Shah Alam, 40450, Shah Alam, Selangor, Malaysia

2Singapore Clinical Research Institute, Singapore

3Institute for Community (Health) Development (I-CODE), Universiti Sultan Zainal Abidin, Block E, Level 1, Gong Badak Campus, 21300, Kuala Nerus, Terengganu, Malaysia

*Corresponding Author E-mail: wanwaj_85@yahoo.com

Online published on 31 October, 2018.


According to World Health Organization (WHO), the estimated annual incidence of osteosarcoma was approximately four to five per million. Differences in demography, culture and belief may give different results in survival for Malaysian compared to other countries. The objective of this study was to determine the five-year survival of osteosarcoma patients treated at Hospital Universiti Sains Malaysia (HUSM). This was a retrospective record review study involving 127 osteosarcoma patients. The recruitment phase of the participants began from 1st August 1995 till 31st July 2006 (11 years) and additional follow up period of twelve months, from 1st August 2006 till 31st July 2007. Patient's survival status was obtained from the medical record as well as contacting their residences by phone call or by home visit with their consent. The Kaplan-Meier was used in statistical analysis. The comparison of survival times in all categorical independent variables groups was done by using log-rank test. The overall median survival time was 47.77 months and overall five-year survival was 48.94% (95% CI: 39.4, 57.8). In type of chemotherapy, neoadjuvant with adjuvant chemotherapy show higher survival rate (70.6%). In type of surgery group, survival rate for limb salvage was the highest (80.5%). As the conclusion, five-year survival for osteosarcoma patients treated was acceptably low.



Five-year survival, Osteosarcoma, Overall median survival, Kaplan-Meier, Malaysia.


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