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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3389) Last page : ( 3391)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00624.8

Role of Anti-anxiety Drugs in Patient Cooperation during Minor Surgical Procedure

Dr. James Divya1,*, Dr. Nazar Nabeel2

1Postgraduate Student, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai

2Reader, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai

*Corresponding Author E-mail: divyajames31@yahoo.com

Online published on 31 October, 2018.



The aim of this study was to assess the behavioral effects and the changes in the anxiety level of adults before and after administration of Alprazolam.

Material and Methods

A total of 40 patients were included in the study, twenty in each group. Subjects were then randomly assigned to receive 0.25 mg oral alprazolam (experiment 1) or no drug (experiment 2). Norman and Corah questionnaire was given to each patient to check their anxiety levels once they entered the clinic. The drug was administered 30 minutes before the oral surgical procedure. Subjects in experiment 1 and 2 subsequently underwent surgery for removal of third molars. Blood pressure and pulse rate was measured both before and during the surgery. The subjects completed anxiety questionnaire before administration of the drug.


The questionnaire results showed that 50% of the patients were tensed, 40% were anxious and only 10% patients were relaxed. The blood pressure after giving Alprazolam was not statistically significant. The pulse rate after giving Alprazolam was statistically significant.


From this study we conclude that Alprazolam can be given for ASA I patients to control their anxiety levels by decreasing their pulse rate.



Alprazolam, analgesics, Benzodiazepine anxiolytics.


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