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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3290) Last page : ( 3294)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00605.4

Colorimetric Determination of Metoclopramide Hydrochloride and Glutathione by using 1,2 Naphthaquinolinc-4-Sulphonate Sodium Reagents

Mashkour Muthana S.*, Kahlol Mohammed K., AL-Hasnawi Sami W.

Department of Chemistry, Faculty of Science, Kufa University, Iraq

*Corresponding Author E-mail: muthanahana74@gmail.com

Online published on 31 October, 2018.

Abstract

Asensitive, simple and accurate spectrophotometric method is developed to the quantitative determination of Metoclopramide hydrochloride and Glutathione drugs. The method depend on the interaction between the amino groups found in drugs with 1,2 Naphthaquinolinc -4-Sulphonate Sodium reagent. The spectra of the products show maximum absorption at 464 and 466 nm and beer's law obeyed at the concentration range of 0.5–20 ppm and 0.3–10 ppm with molar absorptivity 3.5×104 and 3.9×104 L.mole−1.cm−1 and limit of detection (LOD) 0.079 and 0.05 ppm with quantitative limit (LOQ) 0,264 and 0.154 ppm to above drugs respectively. The percent recoveries are 98.79 and 97.39 respectively, and relative standard deviation RSD % are 0.26 and 0.15 respectively. Stability constant are 7.9×1011 and 1.5×1011 with stoichiometry drugs to reagent 1:1 and 1:2 respectively. The method havebeen applied successfully of Metoclopramide in meclodinorel drops and Gluta white capsules and studying the interference of some surfactants on determination method.

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Keywords

Metoclopramide hydrochloride, Glutathione, 1,2 naphthaquinolinc -4-sulphonate sodium, Spectrophotometric.

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