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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3227) Last page : ( 3233)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00593.0

Improvement of Antibiotic Production in fungi

Giang Vo1, Nguyen Dung2, Nguyen Tu1,*

1School of Biotechnology, International University, Vietnam National University, Hochiminh City, Quarter 6, Linh Trung Ward, Thu Duc District, Hochiminh City, Vietnam

2Faculty of Natural Sciences, Thu Dau Mot University

*Corresponding Author E-mail: nhktu@hcmiu.edu.vn

Online published on 31 October, 2018.


Antibiotic formation and their structures are the results of multileveled control in which a network of different processes, intermediate stages and molecules are involved. Antibiotic production requires the special conditions of various nutrients. Carbon, nitrogen and phosphorus are the most important sources which regulate secondary metabolism in distinct ways. Carbon source influences on secondary metabolism through a process called carbon catabolite repression in which the biosynthetic gene transcription is repressed, leading to the prevention of antibiotic production. Nitrogen regulates antibiotic production through a mechanism called nitrogen metabolite repression or nitrogen catabolite repression in which the preferential use of easily assimilated nitrogen sources is enabled while the secondary nitrogen sources is selectively utilized on the condition of exhaustion of primary substrate. Although information about the mechanism of phosphate regulation is very limited, there is still a possibility that phosphate sources control antibiotic production by affecting the activities of enzyme involved in secondary metabolism. The exchange of genes between fungi and other microorganisms can improve antibiotic production. This review focuses on the improvement of antibiotic production in fungi in nutrient conditions supplied directly in medium or through co-culture with other bacteria.



Fungi, antibiotic production, carbon, nitrogen, phosphorus.


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