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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3119) Last page : ( 3122)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00572.3

Method Development and Validation of a new RP-HPLC method for the simultaneous Assay of Ketorolac Tromethamine and Fluorometholone

Chaithanya Sunkara Mrunal*, Annapurna Mukthinuthalapati Mathrusri

Department of Pharmaceutical Analysis and Quality Assurance, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam-530045, India

*Corresponding Author E-mail: mrunal.chaitanya@gmail.com

Online published on 31 October, 2018.

Abstract

A new RP-HPLC method has been developed and validated for the simultaneous determination of Ketorolac tromethamine and Fluorometholone pharmaceutical formulations. Shimadzu Model CBM-20A/20 Alite with C8 Phenomenex column (250 mm × 4.6 mm i.d., 5 μm particle size) was used for the proposed work with a mixture of 0.1M ammonium formate and methanol as mobile phase and flow rate 0.8 ml/min (UV detection at 241 nm). The linear regression equation was found to be y = 35207x + 29529 R2 = 0.9995 for Fluorometholone and y = 68207x + 57590 R2 = 0.9997 for Ketorolac tromethamine and the method was validated.

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Keywords

Fluorometholone, Ketorolac tromethamine, RP-HPLC, validation.

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