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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3077) Last page : ( 3080)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00565.6

The Drug-Drug Interactions: Affecting the Rationality of Prescriptions

Jagadeesan M*, Manikandan R, Sudha Nandamuri Sri Sai

Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203, Tamil Nadu, India

*Corresponding Author E-mail: jagapharmd2013@gmail.com

Online published on 31 October, 2018.


Aim and Objectives

The drug-drug interaction is the primary cause of irrationality prescriptions mostly due to polypharmacy. Drug interactions have caused by the two or more drugs or other substances taken by the same patient. Due to widespread of therapeutic medications and polypharmacy, drug interactions are enormous. The aim of the study to evaluate and assess the drug-drug interactions in tertiary care teaching hospital in South India.


A Retrospective study has conducted by enrolling the prescriptions of outpatients in the hospital who came for patient counselling to Drug information centre during the year of 2017.


In that Out of 350 prescriptions, 110 orders were found to have drug-drug interactions (p<0.0001), in that 33 (21%) were found to be minor, 110 (70%) moderate, 15 (9%) significance major interactions which may require some therapeutic interventions or monitoring.


The frequently occurring drug interactions are seen in Antihypertensive drugs, Diuretics, Proton pump Inhibitors and Antibiotics.



Rational Prescriptions, Irrationality, Drug-Drug interactions, Severe Interactions, Monitoring.


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