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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3043) Last page : ( 3048)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00560.7

Disorders of the Functional State of the Haemostatic System during Intraoperative and Postoperative Anesthesia and their Prevention

Kayukov Leonid1, Agarkova Lubov1, Agarkova Tatiana1,*, Shipakov Vitalyi2, Zakharova Irina3, Bukharina Irina1

1Research Institute of Obstetrics, Gynecology and Perinatology, Tomsk National Research Medical Center, Russian Academy of Sciences

2Department of Anesthesiology, Reanimatology and Intensive Care, Siberian State Medical University, Tomsk, Russia

3Obstetrics and Gynecology Department, Siberian State Medical University, Tomsk, Russia

*Corresponding Author E-mail: agarkova@mail.ru

Online published on 31 October, 2018.

Abstract

The purpose is to develop principles of intra-and postoperative preventive measures against thromboembolic complications in gynaecologic patients with haemostasis system defects. The methods of examining the haemostasis system status included the determination of the platelets level, platelets aggregation, activated partial thromboplastin time (APTT), plasma coagulation time, prothrombin time, international normalized ratio (INR), concentration of fibrinogen in plasma, antithrombin III activity, and D-dimer. A comprehensive analysis of the haemostasis and fibrinolysis system was carried out with the ARP-01 “Mednord” portable analyser of blood rheological properties. Obtained results were statistically processed with the SPSS v.20.0 software (Providence Software Solutions, Inc., USA) with Student's t-test and Mann-Whitney U-test. The comparison of dependent variables used the Wilcoxson W-test. The significance of differences in qualitative attributes was analysed during the frequency analysis with Fisher's exact test and the chi-squared test. The study suggests two differentiated approaches to the prescription of intravenous laser irradiation of blood, based on hemocoagulogram indicators that reflect the structural and chronometric properties of the formed clot.

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Keywords

Uterine myoma, haemostasis, anaesthesia, intravenous laser irradiation of blood.

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