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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3031) Last page : ( 3035)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00558.9

Anti-wrinkle Effects of Mixed Extracts of Three Medicinal Herbs

Ha Hun-Yong1, Yoon Wan-Young2,*

1Dept. of Pharmaceutical Science and Engineering, Seowon University, Cheongju-28674, South Korea

2Dept. of Clinical Exercise Physiology, Seowon University, Cheongju-28674, South Korea

*Corresponding Author E-mail: wanyoung72@gmail.com

Online published on 31 October, 2018.



The utilization of cosmetic raw materials for medicinal purposes in oriental medicine has been increasing on the basis of their eco-friendly image. Methods/Statistical analysis: The anti-wrinkle effects of the extract were assessed on the eye rims. The extract was always applied under the same experimental conditions in a clean and dry state after the patients rested in an air-conditioned room for at least 30 min (22±2°, R.H. 40∼60%). A cutometer (MPA 580, Courage and Khazaka Electronic Co., Germany) was used to measure wrinkle improvements.


The clinical assessment was approved by the Institutional Review Board (IRB). The results of the clinical assessment performed on 22 participants showed an increase in skin elasticity by 12.7% and 11.1% at 2 weeks and 4 weeks after the test initiation, respectively. This result demonstrates that the 3 medicinal herbs can reduce wrinkles caused by aging and may be used as raw materials in the development of cosmetic products. The medicinal herbs caused no irritation in the skin irritation test, and thus, they were clinically proved safe. Through this research, we were able to confirm the safety of medicinal herbs and understand the principles of oriental medicine. The findings of this study may promote the utilization of medicinal herbs in relevant industries. They also suggest the potential of the 3 medicinal herbs, Coptischinensis,Cimicifugaheracleifolia,and Poriacocos (Schw) as raw materials for the development of cosmetic products and topical dermatologic drugs.


The results suggested that an individual medicine, as well as a combination of various medicines, based on the theories of traditional oriental medicine, have certain effects on skin health.



Anti-wrinkle, medicinal herbs, Coptischinensis, Cimicifugaheracleifolia, Poriacocos.


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