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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3003) Last page : ( 3006)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00553.X

Pro-inflammatory Cytokine Production Inhibitory Effects of Everlasting Oil

Kim Jeong-Suk1, Park Jeong-Sook2,*

1Department of Nursing, Nambu University, 23 Jungang-ro, Gwangsan-gu, Gwangju, 62271, Korea

2Department of Nursing, Nambu University, 23 Jungang-ro, Gwangsan-gu, Gwangju, 62271, Korea

*Corresponding Author E-mail: pk0207@nambu.ac.kr

Online published on 31 October, 2018.



This study aims to demonstrate pro-inflammatory cytokine production inhibitory effects using everlasting oil.

Methods/Statistical analysis

Thus, This paper was carried out to see secretion of NO, inflammatory cytokine,TNF-α, IL-1β using the macrophages of LPS-treated mice. The cytotoxicity test was used 96 AQueous One solution cell proliferation assay. No Detection kit was used to measure No,the production of pro-inflammatory cytokine was measured using ELISA kit.


As a result, everlasting oil had no cytotoxicity at 5 ug/mL to 500 ug/mL and significantly inhibited the production of NO as well as TNF-α, IL-1β. In the RAW 264.7 mousemacrpphage cells,Pro-inflammatory cytokine production inhibitory effects are likely to be diversely utilized as basic physiological activity data and functional materials to demonstrate antiinflammatory properties of everlasting oil.


In conclusion, this study can be used to a basic data to objectively demonstrate the physiological activity of immunological mechanism associated with the anti-inflammatory action of everlasting oil, but it is necessary to conduct studies on anti-inflammation.



Everlasting oil, Cytokine, Anti-inflammatory, NO, TNF-α.


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