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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3003) Last page : ( 3006)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00553.X

Pro-inflammatory Cytokine Production Inhibitory Effects of Everlasting Oil

Kim Jeong-Suk1, Park Jeong-Sook2,*

1Department of Nursing, Nambu University, 23 Jungang-ro, Gwangsan-gu, Gwangju, 62271, Korea

2Department of Nursing, Nambu University, 23 Jungang-ro, Gwangsan-gu, Gwangju, 62271, Korea

*Corresponding Author E-mail: pk0207@nambu.ac.kr

Online published on 31 October, 2018.

Abstract

Background/Objectives

This study aims to demonstrate pro-inflammatory cytokine production inhibitory effects using everlasting oil.

Methods/Statistical analysis

Thus, This paper was carried out to see secretion of NO, inflammatory cytokine,TNF-α, IL-1β using the macrophages of LPS-treated mice. The cytotoxicity test was used 96 AQueous One solution cell proliferation assay. No Detection kit was used to measure No,the production of pro-inflammatory cytokine was measured using ELISA kit.

Findings

As a result, everlasting oil had no cytotoxicity at 5 ug/mL to 500 ug/mL and significantly inhibited the production of NO as well as TNF-α, IL-1β. In the RAW 264.7 mousemacrpphage cells,Pro-inflammatory cytokine production inhibitory effects are likely to be diversely utilized as basic physiological activity data and functional materials to demonstrate antiinflammatory properties of everlasting oil.

Improvements/Applications

In conclusion, this study can be used to a basic data to objectively demonstrate the physiological activity of immunological mechanism associated with the anti-inflammatory action of everlasting oil, but it is necessary to conduct studies on anti-inflammation.

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Keywords

Everlasting oil, Cytokine, Anti-inflammatory, NO, TNF-α.

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