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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2848) Last page : ( 2854)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00525.5

Enhanced Solubility and Percutaneous Permeability of Lornoxicam gel using Biosurfactant.

Mr. Bolmal Udaykumar B1,3,*, Dr. Pramod H J2

1Department of Pharmaceutics, KLE College of Pharmacy Belagavi. Karnataka

3KLE Academy of Higher Education and Research, Belagavi. 590010, Karnataka, India

2Department of Pharmaceutical Biotechnology, KLE College of Pharmacy, Belagavi, Karnataka

*Corresponding Author E-mail: udaybolmal@yahoo.co.in

Online published on 31 October, 2018.

Abstract

Objective

Lornoxicam is the anti inflammatory agent under BCS II. Oral use for the chronic condition may cause peptic ulcer. Topical gel formulation is an alternative route of administration to overcome the shortcoming. The present study was aimed at enhancement of solubility and permeation of Lornoxicam using a novel biosurfactant from biotechnology product and compared with a nonionic surfactant (Tween 80).

Methods

Topical gel was prepared by sodium alginate and calcium gluconate as a gelling agent and complexing agents in different concentrations respectively. The drug was solubilized with biosurfactant and Tween 80.

Results

Gels were evaluated for its physical-chemical properties. In vitro and ex vivo permeation studies were carried out through egg membrane and rat skin respectively.G1 formulation showed drug content (98,9%), spreadability (31.36gm/cm2), viscosity (3853mPa.S) with yield value (220Pa.s). Drug permeation study by two methods resulted in an enhancement ratio was 0.856. In vivo anti-inflammatory activity of G1 and marked formulation exhibited 49.9% and 36% percentage of inhibition respectively. The short term stability studies conducted for 3 months revealed that at room temperature (25oc±1oc and RH 40%) optimized formulation was stable without much variation in drug content, viscosity, pH, and in vitro drug release study.

Conclusion

Lornoxicam gel is promising natural polymer based preparation to be used for topical application.

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Keywords

Lornoxicam, Biosurfactant, nonionic surfactant, natural gelling agent, permeability.

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