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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2809) Last page : ( 2813)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00518.8

Molecular Characterizations of Aminoglycoside Modifying Enzymes of Proteus mirabilis Isolated From Patients in Al-Qadisiyah Governorate

AL-Oqaili Najlaa Abdallah D.1,*, AL-Shebli Majed Kadim2, Almousawi Azhar N. H.3

1College of Biotechnology, University of Al-Qadisiyah, Iraq

2College of Education, University of Al-Qadisiyah, Iraq

3College of Pharmacy, University of Al-Qadisiyah, Iraq

*Corresponding Author E-mail: najlaa67890@gmail.com

Online published on 31 October, 2018.

Abstract

The aim of this study was evaluate the presence of modified enzymes for aminoglycosides antibiotics in Proteus mirabilis. Total of 64 clinical isolates were collected from various sources included urine, middle ear, wounds, burns, high cervical and endometrium cervical, which was taken from in patients and outpatients in Maternal, and General Teaching Hospital in AL-Diwaniya city during the period from 1/3/2015 till 30/9/2015. Select the minimum inhibitory concentration of a number of antibiotics for aminoglycosides for resistant bacterial isolates which are anti-Gentamycin, Tobramycin, Kanamycin, Streptomycin, Netlimicin the isolates showed their ability to grow in high concentrations ranging from (32–1024)μg/ml, also resisted anti-aminoglycosides and with different rates of Gentamycin, Amikacin, Tobramycin, Kanamycin, Streptomycin, and Netlimicin, it was in varying proportions (54.68, 31.25, 76.56, 81.25, 85.93, 81.25) %, respectively.

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Keywords

Aminoglycoside, Modifing Enzymes, proteus mirabilis, PCR, MIC, Aminoglycoside antibiotics.

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