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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2804) Last page : ( 2808)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00517.6

Formulation and Evaluation of directly compressed Floating Tablets of Candesartan Cilexetil for Gastro Retentive Drug Delivery

Agrawal Palak, Ajazuddin, Banjare Tripti, Gupta Swapnil, Bhandarkar Akansha, Sahu Hemlata, Diwedi Shradha Devi, Sahu Pankaj, Sahu Siddharth Kumar, Yadav Pooja, Bhatt Aditi, Sahu Kailash, Dewangan Deeksha, Thapa Hemlata, Deepika, Sahu Gyanesh, Sharma Mukesh, Tripathi D. K., Alexander Amit*

Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: itsmeamitalex@gmail.com; dramitalexander@gmail.com

Online published on 31 October, 2018.

Abstract

The candesartan cilexetil floating matrix drug delivery system was design to prolong the gastric residence time and improve its bioavailability. The candesartan cilexetil floating matrix tablet was prepared by using direct compression technique. Various natural polymer such as xanthan gum, guar gum as well as synthetic polymer such as hydroxypropyl methyl cellulose used in combination along with other standard excipients. Here, sodium bicarbonate acts as gas-generating agent. The granules undergoes through pre and post compression studies. The tablet evaluated by using various evaluating parameter viz, hardness, friability, weight variation, content uniformity, floating capacity and in vitro drug release studies.

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Keywords

Candesartan, Cilexetil, Gastro Retentive, Floating Tablet.

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