In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity Usharani S*, Anuradha R. PG and Research Department of Biochemistry, S.T.E.T.Women's College, Sundarakottai, Mannargudi–614001. Tamil Nadu, India *Corresponding Author E-mail: usharani1886@gmail.com
Online published on 31 October, 2018. Abstract Objective The In vivo antioxidant and modulating enzymes of the Wattakaka volubilis leaves and kaempferol against aluminium sulphate induced toxicity in rats. Methods Hepatotoxic rats were treated with methanol extract of Wattakaka volubilis and kaempferol for a period of 14 days. Results The activities of LPO, SOD, CAT, GSH, GR, GPx and membrane bound enzymes, Mitochondrial enzymes in liver. The activities of all parameters registered a significant (p≤0.001) alteration in aluminium sulphate treated rats, which were significantly recovered towards an almost normal level in rats co-administered with Wattakaka volubilis extract in a dose-dependent manner. All the biochemical investigations were confirmed by the observations and compared with the standard drug silymarin. Conclusion Antioxidant enzymes, membrane bound ATPase, mitochondrial TCA cycle enzymes enzymes modulated by kaempferol on aluminium sulphate induced liver toxicity. Top Keywords Antioxidants, free radicals, hepatoprotection, Wattakaka volubilis, Mitochondrial enzymes, membrane bound enzymes. Top |