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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2555) Last page : ( 2560)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00472.9

New Azomethine-Azo heterocyclic ligands via cyclization of ester

Mohammed Mieaad1, Dr. Aljamali Nagham Mahmood2,*, Shubber Wassan Ala2, Abdalrahman Sabreen Ali2

1Assistant Lecturer, Chemistry Department Faculty of Sciences, Iraq

2Department of Chemistry, Faculty of Education, Iraq

*Corresponding Author E-mail: Dr. Nagham_mj@yahoo.com

Online published on 24 August, 2018.

Abstract

Cyclization reaction has been used to preparation of series heterocyclic azo-azomethine ligands through many steps, the first step: esterification of carboxylic terminal, then cyclization of ester with thiosemicarbazide, followed by second step which involved azotation of amino group of thiadiazole, the third step was reacted with di carbonyl compound, the last step involved cyclization with compounds containing di nucleophile groups to yield series azo heterocyclic-azomethine ligands. The resulting ligands were investigated bymany techniques like (1H NMR, FT.IR and UV-Visible spectra) with biological test.

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Keywords

Thiadiazole, thiosemicarbazide, ester, cyclization, azo, imidazole, azomethine, thiazane, thioamide, thiophene.

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