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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2503) Last page : ( 2506)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00462.6

The effect of yolk immunoglobulin and heat killed Sallmonella typhi on rabbits

Abdulazeem Lubna1, Jassim Yaziabdullah2,*

1University of Babylon, DNA Research Center, Iraq

2Biology Department, College of Science, Babylon University, Hilla, Iraq

*Corresponding Author E-mail: vitarani.ningrum@uii.ac.id

Online published on 24 August, 2018.

Abstract

Yolkimmunoglobulin (IgY) was purified from chicken egg to study its effect on groups of rabbits immunized with heat killed Sallmonellatyphi in immunization program. Four groups of rabbits (5 rabbits in each groups) were immunized.the first group immunized with yolk immunoglobulin, the second with heat killed bacteria, the third with mixed (IgY and heat killed bacterial antigen) and the fourth with normal saline as controls. The effect of IgY was be clarified by increasing the concentration of IgM, IgG, IL4and IL8 in serum of the immunized rabbits compared to the control group. Skin test showed the effect of the bacterial antigen on sensitivity of rabbits and the extent of affected on cellular immunity.

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Keywords

(Egg yolk IgY, Salmonella typhi, immunoglobulin G and M, cytokines IL-4 and IL-8).

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