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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2463) Last page : ( 2467)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00454.7

Dysphagia survey using 24-Hour multichannel intraluminal impedance-pH (MII-PH) monitoring tests in patients with nonerosive reflux disease (NERD): A case-Control study

Yaseri Hashem Fakhre1,*

Gastrointestinal and Liver Diseases Research Center, Gastroenterology, Iran University of Medical Sciences (GILDRC), Firoozgar Hospital, Tehran, Iran

1Department of Internal Medicine, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

*Corresponding Author E-mail: hfyaseri@chmail.ir

Online published on 24 August, 2018.



Dysphagia is defined as an abnormal delay in transit of a liquid or solid bolus during the oropharyngeal or esophageal stages of swallowing. Recently, it was reported that dysphagia can be associated with uncomplicated Gastroesophageal reflux disease (GERD). The present study aimed at screening dysphagia in patients with nonerosive reflux disease (NERD), who presented with dysphagia using some monomeric criteria and 24-hour multichannel intraluminal impedance-pH (MII-PH) monitoring tests. Method: This casecontrol study was conducted on 360 patients with nonerosive gastroesophageal reflux disease (NERD). The case group included 150 NERD patients with dysphagia and control group consisted of 210 NERD patients without dysphagia. Esophagogastroduodenoscopy (EGD), Esophageal manometry and esophageal multichannel intraluminal impedance-pH (MII-pH) monitoring tests were performed for all patients


In contrast to patients without dysphagia (control group), dysphagia in case group was more prevalent in females (57.3%)than in males (42.7%)(p=0.42).61.3%(92/150) and 38.1(80/210) of patients with and without dysphagia had mixed reflux in upright position, respectively (p = 0.03).61.3%(92/150) and 34.3%(72/210) of of patients with and without dysphagia had gas reflux in upright position, respectively (p = 0.03). The prevalence of weakly acid reflux in patients with and without dysphagia, in upright positions, were 40.7%(61/150) and 27.6(58/210), respective ly (p = 0.26).


Mixed and gas reflux were more prevalent in patients with dysphagia than in those without dysphagia, especially in upright position. Moreover, weakly acid reflux in NERD patients with dysphagia was more frequent than in those without dysphagia.



NCCP, NERD, Regurgitation, MII-pH.


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