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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2444) Last page : ( 2453)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00451.1

Formulation and Evaluation of Bilayer Gastric Mucoadhesive Patch of Captopril

Dr. Bhilegaonkar Shilpa P.*, Volvoikar Sharayu G., Naik Anisha G.

Department of Pharmaceutics, P.E.S`s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda-Goa, 403401

*Corresponding Author E-mail: shilpabhilegaonkar@gmail.com

Online published on 24 August, 2018.


The goal of the present investigation was to design and evaluate bilayered gastro-retentive mucoadhesive patches of Captopril. Captopril is a potent ACE inhibitor, widely used in the treatment of hypertension. Given orally, Captopril is absorbed rapidly and has a bioavailability of 75%, peak plasma concentrations occur within an hour and is cleared rapidly with a short biological half-life of about 2–3 hours. The drug is freely soluble in water and has site specific absorption from GIT. The drug is unstable in alkaline pH of intestine, where as stable in acidic pH and specifically absorbed from stomach. All these factors may lead to fluctuations in bioavailability, thus the present research proposes a formulation to overcome the above mentioned problems, by formulating an oral bilayered gastric mucoadhesive patch of Captopril. The bilayered patch consists of an immediate release layer made up of HPMC E15, a mucoadhesive layer composed of polymers: Chitosan and HPMC K15. The patches were evaluated for their thickness, weight variation, folding endurance, swelling behavior, unfolding study, mucoadhesive strength and time. In-vitro drug release studies were conducted for the Captopril loaded patches in 0.1N HCl and a maximum release was shown by formulation F8 (96.73%) in 12 hours. The data of invitro drug release was fitted into kinetic models (Zero order, First order, Higuchi and Korsmeyer-Peppas models) to explain the release kinetics and mechanism of release, which inturn was found to follow zero order kinetics with non-fickian diffusion. The prepared patch was found to be stable for three months at accelerated storage conditions according to ICH.



Captopril, bilayer, mucoadhesion, sustained release, gastric retention.


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