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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2429) Last page : ( 2433)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00448.1

Formulation and evaluation of levocetrizine orodispersible tablet

Sahu Pankaj, Alexander Amit, Agrawal Palak, Banjare Tripti, Bhandarkar Akansha, Gupta Swapnil, Sahu Hemlata, Diwedi Shradha Devi, Sahu Siddharth Kumar, Yadav Pooja, Sahu Kailash, Bhatt Aditi, Dewangan Deeksha, Thapa Hemlata, Deepika, Sahu Gyanesh, Sharma Mukesh, Tripathi D. K., Ajazuddin*

Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: write2ajaz@gmail.com, ajazuddin@rungta.ac.in

Online published on 24 August, 2018.

Abstract

Orodispersible tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. Allergic rhinitis is a high-prevalence chronic respiratory disease with a negative impact on the subject's quality of life, work activities, productivity or school performance as well as on healthcare costs. Because of its benign nature, the importance of this condition is often underestimated. In the present study orodispersible tablet of antihistaminic agent was prepared by direct compression method using crosspovidone, Crosscarmellose as superdisintegrants. The tablets prepared were evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and In-vitro dissolution time. All the parameters were found to be within limits. The developed formulation oflevocetirizine batch F6 (crosspovidone) showed good palatability and dispersed within 30 seconds as compare to crosscarmellose sodium.

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Keywords

Orodispersible tablet, Levocetirizinedihydrochloride, antihistaminic agents, super disintegrants.

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