Chemical analysis and anticancer effects of Juniperus polycarpos and oak gall plants extracts
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The seeds of Juniperus polycarpos and Oak Gall (distortion of leave buds of Quercus infectoria)were investigated for chemical composition by Gas Chromatography Mass Spectrum (GC-MS)and studied their anticancer activity. Sixty-five different compounds recognized in crudefruits extract of J.polycarpos. The major three components were: 2(10)-Pinene, (1S, 5S)-(−)-(17.78%), 2-Hexanol, 2-methyl-(21.14%) and 2, 4-Decadienal (8.72%). They were presence of thirty-four compounds in the crud extract of Oak Gall. The highest strong peak area (69.4%) was obtained by 2-Hexanol, 2-methyl-fallowed by 2, 4-Decadienal (6.79%) and Eucalyptol (5.17%). There are some similar compounds in these plants. 2-Octenal, (E)-; 2, 4-Decadienal and Hexanoic acid is exactly the same compounds found in alcohol extracts of J.polycarpos and Oak Gall. Moreover, 2-Heptenal, (Z)-; 2-Hexanol, 2-methyl-; Copaene; 2-Decenal, (Z)-;.alpha.-Terpieol and 2, 4-Decadienal, (E, E)were found in J.polycarpos and in Oak Galls All of concentrations of crud plant extracts of J.polycarpos and Oak Gall had high reductions to mice mammary carcinoma cell line 2003 AMN3 cancer cell line, their half maximal inhibitory concentration (IC50) 2 microgram per milliliterand 0.2 milligram per milliliter respectively. Less reductions found on recombinant mouse epithelial cell line (L20B) cell line. IC50 of J. polycarposwere: 0.2 mg/ml.
Cell line, GC-MS, Juniperus polycarpos, Oak Gall.