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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2351) Last page : ( 2356)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00436.5

Analytical spectrophotometric study for determining hydrocholrothiazide individually or with combination with triametrene in some pharmaceutical formulations

Antakli Saad*, Nejem Leon, Kullah Ahmad

Department of Chemistry, Faculty of Science, University of Aleppo, Syria

*Corresponding Author E-mail: antakli@scs-net.org

Online published on 24 August, 2018.

Abstract

Spectrophotometric method was developed and applied for simultaneous determination of Hydrochlorothiazide (HYD) individually or with combination with Triamterene (TRM) in some pharmaceutical formulations. This new method was applied to determine (HYD) and (TRM) in several Syrian trademark drugs such as: (Biazid 50 mg (TRM) and 25 mg (HYD)/tab, Hydrochlorothiazide Alfares 25 mg/tab, Hydrochlorothiazide Alfares 12.5 mg/tab, DIUREX 25 mg/tab). Derivative spectrophotometric (DS) method was applied for the determination of (HYD) and (TRM), respectively. (HYD) was determined by first derivative spectrophotometry at 280.5 nm (1D 280.5), and (TRM) was determined by first derivative spectrophotometry at 379 nm (1D 379). Linearity ranges were 0.64–28.8 μg/mL for (HYD) and 0.8–19.2 μg/mL for (TRM), regression analysis showed a good correlation coefficients R2 = 0.9997 and R2 = 0.9999 for (HYD) and (TRM), respectively. The limit of detection (LOD) and limit of quantification (LOQ) were to be 0.143 μg/mL and 0.433 μg/mL for (HYD), 0.128 μg/mL and 0.390 μg/mL for (TRM), respectively. 0.134 in table 1 The proposed derivative method was successfully applied to analysis individual or mixture of (HYD) and (TRM) in Syrian trademark drugs. All studied samples showed that the drug levels were conformed to united state pharmacopeia (USP) legislation.

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Keywords

Hydrochlorothiazide, Triamterene, Derivative Spectrophotometry.

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